Faculty Directory
Arun Sharma

Research Associate Professor of Urology

Research Associate Professor of Biomedical Engineering

Contact

303 East Superior Street
Simpson Querrey Institute Room 11-223
Chicago IL 60611

312-503-1101Email Arun Sharma

Departments

Biomedical Engineering

Education

PhD    University of Illinois at Chicago, Pathology, Department of Medicine, 2002

BA      University of California at Santa Cruz, Biochemistry and Molecular Biology, 1994



Selected Publications

Szilvassy S, Weller K, Lin W, Sharma AK, Ho A, Tsukamoto A, Hoffman R, Leiby K, Gearing D. Leukemia inhibitory factor upregulated cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood 1996 87:4618-4628

Uchida N, Yang Z, Combs J, Pourquie O, Nguyen M, Ramanathan R, Fu J, Welpy A, Chen S,  Weddell G, Sharma AK, Leiby K, Karagogeos D, Hill B, Humeau L, Stallcup H, Hoffman R, Tsukamoto A, Gearing D, Peault B. The molecular cloning and expression of a novel hematopoietic cell antigen (HCA) from CD34+ human bone marrow cells. Blood 1997 89:2706-2716

Van Den Berg D, Sharma AK, Bruno E, Hoffman R. Roles of members of the Wnt gene family in human hematopoiesis. Blood 1998 92:3189-3202

Wickrema A, Uddin S, Sharma AK, Chen F, Alsayed Y, Ahmad S, Sawyer T, Krystal G, Yi T,  Nishada K, Hibi M, Hirano T, Platanias L. Engagement of Gab1 and Gab2 in Erythropoietin signaling. JBC 1999 35: 24469-24474

Sharma AK, Nelson M, Brandt J, Wessman M, Mahmud N, Weller K, Hoffman R. Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood 2001 97:426-434

Johnson K, Dukes K, Vidaver J, LeShane E, Ramirez I, Weber W, Bischoff F, Hahn S, Sharma AK, Dang D, Hire L, Bianchi D, Simpson J, Holzgreve W, Elias S, Klinger K. Interlaboratory Comparison  of Fetal Male DNA Detection from Common Maternal Plasma Samples by Real-Time PCR. Clin Chem. 2004 Mar; 50(3): 516-521

Gussin HA, Sharma AK, Elias S. Culture of endothelial cells isolated from maternal blood using anti- CD105 and CD133. Prenat Diagn 2004 Mar 24(3): 189-193.

Ibanez V, Sharma AK, Buonamici S, Verma A, Kalakonda S, Wang J, Kadkol S, Saunthararajah Y. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. Cancer Res. 2004 Jul; 64(13): 4547-54.

Gussin HAE, Sharma AK, Elias, S. Culture of cells from maternal circulation, in conditions favoring fetal endothelial cells expansion, does not facilitate the preferential expansion of circulating fetal cells. Fetal Diagn Ther 2005; 20:64-69.

Sharma AK, Belna J, Logan J, Espat J, Hurteau J. The effects of Omega-3 fatty acids on growth regulation of epithelial ovarian. Gynecol Oncol. 2005 Oct;99(1):58-64.

Harrington DA, Sharma AK, Erickson BA, Cheng EY. Bladder tissue engineering through nanotechnology. World J Urol. 2008 Aug;26(4):315-22.

Bedi R, Du J, Sharma AK, Gomes I, Ackerman SJ. Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. Blood. 2009 Jan 8;113(2):317-27.

Sharma AK, Donovan JL, Hagerty JA, Sullivan RR, Edassery SL, Harrington DA, Cheng EY. Do current bladder smooth muscle cell isolation procedures result in a homogeneous cell population? Implications for bladder tissue engineering. World J Urol. 2009 Oct; 27(5):687-94.

 Sharma AK, Belna J, Espat J, Rodriguez G, Cannon V, Hurteau J. Effects of omega-3 fatty acids on components of the pathway: implication for dietary modification in prevention of ovarian cancer. Am J Obstet Gynecol. 2009 May; 200(5):516.e1-6.

Sharma AK, Fuller N., Sullivan R., Fulton N., Hota P., Harrington DA., Hagerty JA., Villano J., Cheng EY. Defined populations of bone marrow derived mesenchymal stem and endothelial progenitor cells for urinary bladder regeneration J Urol. 2009 Oct; 182(4 Suppl):1898-905.

Sharma AK, Hota P, Matoka DJ, Fuller N, Jandali D, Thaker H, Ameer GA, Cheng EY. Urinary bladder regeneration utilizing bone marrow derived mesenchymal stem cell seeded elastomeric poly(1,8-octanediol-co-citrate) based thin films. Biomaterials. 2010 Aug; 31(24):6207-17

Sharma AK, Bury MI, Marks AJ, Fuller NJ, Meisner JW, Tapaskar N, Halliday LC, Matoka DJ, Cheng EY. A non-human primate model for urinary bladder regeneration utilizing autologous sources of bone marrow derived mesenchymal stem cells. Stem Cells. 2011 Feb;29(2):241-50.

Chow LW, Bitton R, Webber MJ, Carvajal D, Shull KR, Sharma AK, Stupp SI. A bioactive self- assembled membrane to promote angiogenesis. Biomaterials. 2011 Feb;32(6):1574-82.

 Hu Z, Gu X, Baraoidan K, Ibanez V, Sharma A, Kadkol S, Munker R, Ackerman S, Nucifora G, Saunthararajah Y. RUNX1 regulates corepressor interactions of PU.1 Blood. 2011 Jun 16;117(24):6498-508.

Sharma AK. An examination of regenerative medicine-based strategies for the urinary bladder. Regen Med. 2011 Sep;6(5):583-98.

Kollhoff DM, Cheng EY, Sharma AK. Urologic applications of engineered tissue. Regen Med. 2011 Nov;6(6):757-65.

Sharma AK, Bury MI, Fuller NJ, Rozkiewicz DI, Hota PV, Kolhoff D, Webber MJ, Tapaskar  N, Meisner JW, Wang D, Ameer GA, Cheng EY. Growth factor release from a chemically modified elastomeric poly(1,8-octanediol-co-citrate) thin film promotes angiogenesis in vivo. J Biomed Mater Res A. 2012 Mar;100(3):561-70.

Thaker H, Sharma AK. Engaging stem cells for customized tendon regeneration. Stem Cells International 2012; 2012:309187.

Drewa T, Adamowicz J, Sharma AK. Tissue engineering for the oncologic urinary bladder: limitations and perspectives. Nature Reviews Urology 2012 Oct;9(10):561-72.

Sharma AK, Bury MI, Fuller NJ, Marks AJ, Kollhoff DM, Rao MV, Hota PV, Matoka DJ, Edassery SL, Thaker H, Sarwark JF, Janicki JA, Ameer GA, Cheng EY. Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4003-4008.

Thaker H, Sharma AK. Regenerative medicine based applications to combat stress urinary incontinence. World J Stem Cells. 2013 Oct 26;5(4):112-123.

Sharma AK. Is a functional urinary bladder attainable through current regenerative medicine strategies? Central European Journal of Urology. 2013 66:207-208.

Pokrywczynska M, Adamowicz J, Sharma AK, Drewa T. Human urinary bladder regeneration through tissue engineering - An analysis of 131 clinical cases. Exp Biol Med (Maywood). 2014 Mar;239(3):264-71.

Hofer MD, Bury MI, Park E, Xu W, Hong J, Kaplan WE, Cheng EY, Sharma AK. Analysis of primary urethral wound healing in the rat. Urology. 2014 Jul;84(1):246.e1-7.

Bury MI, Fuller NJ, Meisner JW, Hofer MD, Webber MJ, Chow LW, Prasad S, Thaker H, Yue X, Menon VS, Diaz EC, Stupp SI, Cheng EY, Sharma AK. Anti-inflammatory nanofibers promote functional urinary bladder regeneration.  Biomaterials 2014 Nov;35(34):9311-21.

Sharma AK, Cheng EY. Growth factor and small molecule influence on urological tissue regeneration utilizing cell seeded scaffolds. Advanced Drug Delivery Reviews 2015 Mar;82-83:86-92.

Hofer MD, Cheng EY, Bury MI, Park E, Xu W, Hong SJ, Kaplan WE, Sharma AK. Analysis of primary urethral wound healing in the rat. Urology. 2014 Jul;84(1):246.e1-7.

Hofer MD, Cheng EY, Bury MI, Xu W, Hong SJ, Kaplan WE, Sharma AK. Androgen supplementation in rats increases the inflammatory response and prolongs urethral healing. Urology. 2015 Mar;85(3):691-7.

Snow-Lisy DC, Diaz EC, Bury MI, Fuller NJ, Hannick JH, Ahmad N, Sharma AK. The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration. PLoS One. 2015 Sep 23;10(9):e0138643.

Hofer MD, Morey AF, Sheth K, Tausch TJ, Siegel J, Cordon BH, Bury MI, Cheng EY, Sharma AK, Gonzalez CM, Kaplan WE, Kavoussi NL, Klein A, Roehrborn CG. Low Serum Testosterone Level Predisposes to Artificial Urinary Sphincter Cuff Erosion. Urology. 2016 Jul 20. pii: S0090- 4295(16)30422-8.