Faculty Directory

Igor Efimov

Professor of Biomedical Engineering

Professor of Medicine (Division of Cardiology)

Director of Graduate Studies for Biomedical Engineering

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The Efimov Lab

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Research Interests

Igor Efimov’s Research Interests: My Cardiovascular Engineering laboratory focuses on the physiological mechanisms of cardiovascular disease and on developing novel therapies for heart diseases with an emphasis on heart rhythm disorders and heart failure. Two engineering strategies are pursued: (1) development of novel implantable, interventional, and wearable bioelectronic devices for real-time device-based diagnostics and therapy of heart diseases and sudden cardiac death; (2) development of novel approaches to bioinformatics and machine learning to diagnose early stages or predisposition to heart disease and to guide the development of novel therapies. 

Selected Publications

• Deviatiiarov, Ruslan M.; Gams, Anna; Kulakovskiy, Ivan V.; Buyan, Andrey; Meshcheryakov, Georgy; Syunyaev, Roman; Singh, Ramesh; Shah, Palak; Tatarinova, Tatiana V.; Gusev, Oleg; Efimov, Igor R., An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure, Nature Cardiovascular Research (2023).
• Lin, Zexu; Kireev, Dmitry; Liu, Ning; Gupta, Shubham; LaPiano, Jessica; Obaid, Sofian N.; Chen, Zhiyuan; Akinwande, Deji; Efimov, Igor R., Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment, Advanced Materials (2023).
• Ausra, Jokubas; Madrid, Micah; Yin, Rose T.; Hanna, Jessica; Arnott, Suzanne; Brennan, Jaclyn A.; Peralta, Roberto; Clausen, David; Bakall, Jakob A.; Efimov, Igor R.; Gutruf, Philipp, Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation, Science Advances (2022).
• Yin, Rose T.; Chen, Sheena W.; Benjamin Lee, K.; Choi, Yeon Sik; Koo, Jahyun; Yang, Quansan; Napolitano, Michael A.; Ausra, Jokubas; Holleran, Timothy J.; Lapiano, Jessica B.; Alex Waters, E.; Brikha, Anlil; Kowalik, Grant; Miniovich, Alana N.; Knight, Helen S.; Russo, Bender A.; Kiss, Alexi; Murillo-Berlioz, Alejandro; Efimova, Tatiana; Haney, Chad R.; Gutruf, Philipp; Rogers, John A.; Trachiotis, Gregory D.; Efimov, Igor R., Open thoracic surgical implantation of cardiac pacemakers in rats, Nature Protocols (2023).
• Chen, Zhiyuan; Lin, Zexu; Obaid, Sofian N.; Rytkin, Eric; George, Sharon A.; Bach, Christopher; Madrid, Micah; Liu, Miya; LaPiano, Jessica; Fehr, Amy; Shi, Xinyu; Quirion, Nathaniel; Russo, Benjamin; Knight, Helen; Aduwari, Anthony; Efimov, Igor R.; Lu, Luyao, Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology, Science Advances (2023).
• George, Sharon A.; Lin, Zexu; Efimov, Igor R., Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessment, Communications Biology (2022).
• Zhu, Ching; Rajendran, Pradeep S.; Hanna, Peter; Efimov, Igor R.; Salama, Guy; Fowlkes, Charless C.; Shivkumar, Kalyanam, High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones, JCI Insight (2022).
• Choi, Yeon Sik; Jeong, Hyoyoung; Yin, Rose T.; Avila, Raudel; Pfenniger, Anna; Yoo, Jaeyoung; Lee, Jong Yoon; Tzavelis, Andreas; Lee, Young Joong; Chen, Sheena W.; Knight, Helen S.; Kim, Seungyeob; Ahn, Hak Young; Wickerson, Grace; Vázquez-Guardado, Abraham; Higbee-Dempsey, Elizabeth; Russo, Bender A.; Napolitano, Michael A.; Holleran, Timothy J.; Razzak, Leen Abdul; Miniovich, Alana N.; Lee, Geumbee; Geist, Beth; Kim, Brandon; Han, Shuling; Brennan, Jaclyn A.; Aras, Kedar; Kwak, Sung Soo; Kim, Joohee; Waters, Emily Alexandria; Yang, Xiangxing; Burrell, Amy; Chun, Keum San; Liu, Claire; Wu, Changsheng; Rwei, Alina Y.; Spann, Alisha N.; Banks, Anthony; Johnson, David; Zhang, Zheng Jenny; Haney, Chad R.; Jin, Sung Hun; Sahakian, Alan Varteres; Huang, Yonggang; Trachiotis, Gregory D.; Knight, Bradley P.; Arora, Rishi K.; Efimov, Igor R.; Rogers, John A., A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy, Science (2022).