Faculty Directory
Shih-Ting (Christine) Wang

Assistant Professor of Materials Science and Engineering (beginning on February 1, 2025)

Assistant Professor, Feinberg School of Medicine (Pulmonary and Critical Care)

Contact

2145 Sheridan Road
Tech
Evanston, IL 60208-3109

Email Shih-Ting (Christine) Wang

Departments

Materials Science and Engineering

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Education

PhD, Materials Science, Imperial College London, London, United Kingdom

M.S., Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan

B.S., Summa Cum Laude, Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan


Research Interests

Well-defined and multifunctional materials are required to probe and perturb complex biological systems and improve the quality of human health. My research broadly aims to advance active nanoscale structures and systems to study dynamic biological processes and address a variety of health-related problems.

Our lab uses interdisciplinary approaches from material science, synthetic chemistry, and experimental biology to create novel enabling technologies, bridging the gap between materials development and biological/translational applications. We are currently interested in the fabrication of artificial structures through rational design and engineering of biomolecular building blocks that can manage interactions at the bio-nano interface and respond to spatiotemporal cues. Specific applications are exploited for early detection and monitoring of disease, profiling of multi-cellular interactions, and tool development for visualization of molecular and cellular processing in vitro and in vivo.



Significant Recognition

  • Ludwig Center and Koch Institute Postdoctoral Fellowship, Massachusetts Institute of Technology (2023-2024)
  • Staff Highlight: "Shih-Ting (Christine) Wang: Designing Materials for Biomedicine," Brookhaven National Laboratory (2021)
  • Engineering and Physical Sciences Research Council i-Sense Mobility Fellowship (2016-2017)
  • Taiwan Semiconductor Manufacturing Company Graduate Fellowship (2012)

Significant Professional Service

  • Reviews user proposals for the Center for Functional Nanomaterials of Brookhaven National Laboratory (2021-present).
  • Mentor of The Junior Academy of The New York Academy of Sciences (2022)

Selected Publications

  1. C. Martin-Alonso, S. Tabrizi, K. Xiong, T. Blewett, S. Sridhar, A. Crnjac, S. Patel, Z. An, A. Bekdemir, D. Shea, S. -T. Wang, S. Rodriguez-Aponte, C. A. Naranjo, J. Rhoades, J. Kirkpatrick, H. Fleming, A. Amini, T. R. Golub, J. C. Love, S. N. Bhatia, V. A. Adalsteinsson. Priming agents improve in vivo recovery of cell-free DNA and enhance the sensitivity of liquid biopsies. Science, 2024, 383, 6680. 
  2. C. Chen, Y. Wu, S. -T. Wang, N. Berisha, M. Manzari, K. Vogt, O. Gang, D. A. Heller. Fragment-Based Drug Nanoaggregation Reveals Drivers of Self-Assembly. Nature Communications, 2023, 14, 8340.
  3. S. -T. Wang, H. Zhang, S. Xuan, D. Nykypanchuk, Y. Zhang, G. Freychet, B. Ocko, R. N. Zuckermann, N. Todorova, O. Gang. Compact Peptoid Molecular Brushes for Nanoparticle Stabilization. Journal of the American Chemical Society, 2022, 44, 18, 8138–8152.
  4. S. -T. Wang, B. Minevich, J. Liu, H. Zhang, D. Nykypanchuk, W. Liu, J. Byrnes, L. Bershadsky, Q. Liu, T. Wang, G. Ren, O. Gang. Designed and Biologically Active Protein Lattices. Nature Communications, 2021, 12: 3702. 
  5. S. -T. Wang, M. A. Gray, S. Xuan, Y. Lin, A. I. Nguyen, N. Todorova, M. M. Stevens, C. R. Bertozzi, R. N. Zuckermann, O. Gang. DNA Origami Protection and Molecular Interfacing through Engineered Sequence-Defined Peptoids. Proceedings of the National Academy of Sciences, 2020, 117, 6339‒6348.
  6. S. -T. Wang, Y. Lin, N. Todorova, Y. Xu, M. Mazo, S. Rana, V. Leonardo, C. D. Spicer, A. A. Edwards, B. Alexander, S. J. Matthews, I. Yarovsky, M. M. Stevens. Facet Dependent Islet Amyloid Polypeptide Interactions with Gold Nanoparticles: Implications for Fibril Formation and Peptide Induced Lipid Membrane Disruption. Chemistry of Materials, 2017, 29, 1550‒1560.
  7. S. -T. Wang, Y. Lin, R. K. Spencer, A. I. Nguyen, M. R. Thomas, N. Amdursky, E. T. Pashuck, S. C. Skaalure, C. Song, P. A. Parmar, R. M. Morgan, P. Ercius, S. Aloni, R. N. Zukermann, M. M. Stevens. Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide Derived β-Sheet Fibrils. ACS Nano, 2017, 11, 8579‒8589.

Patents

S. -T. Wang, O. Gang, R. N. Zuckermann, C. R. Bertozzi. Side Chain Modified Peptoids Useful as Structure-Stabilizing Coating for Biomaterials. U.S. Patent Application 17/015,532.