News & Events / BME Seminar Series / Past Seminar Speakers / 2017-18Craig Duvall, PhD
BME Seminar Series Spring 2018
Thursday, April 19, 2018 at 4-5 pm
Tech L361
Host: Professor Guillermo Ameer
Associate Professor of Biomedical Engineering, Vanderbilt University
Precision Polymer Architectures and Conjugates to Enable Molecularly-Targeted and Cell-based Therapies
The Duvall Advanced Therapeutics Laboratory (ATL) in the Department of Biomedical Engineering at Vanderbilt University (Nashville, Tennessee, USA) specializes in design and application of smart polymer-based technologies for: (1) intracellular delivery of biological drugs such as peptides and nucleic acids, (2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and (3) long-term, “on-demand” drug release from localized depots. These delivery systems are designed to improve the therapeutic index of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be “undruggable”. To achieve optimal, finely-tuned therapeutic properties, polymers are utilized that respond to one or more environmental stimuli including pH, matrix metalloproteinases, reactive oxygen species, and temperature. This talk will focus on the latest innovations from our group focused on development of molecularly-targeted. RNAi-based breast cancer therapies, improving longevity of autologous vascular bypass transplants, and development of ROS-responsive biomaterials for tissue regenerative applications.
Learn more about Professor Craig Duvall and their research here.