News & Events / BME Seminar Series / Past Seminar Speakers / 2018-19Ngan Huang, PhD
BME Seminar Series Spring 2019
Thursday, March 18, 2019 at 4-5 pm
Hughes Auditorium, Lurie Research Center
303 E Superior St, Chicago, IL 60611
Host: Professor Jason Wertheim
Assistant Professor of Cardiothoracic Surgery, Stanford University
Principal Engineer, Veterans Affairs Palo Alto Health Care System
Engineering the Microvasculature for Regenerative Medicine
In this talk, Dr. Huang will discuss the role that nano-scale geometric patterning and chemical composition of ECM proteins in modulating endothelial differentiation, endothelial function, and angiogenic capacity. Dr. Huang will discuss ongoing work to utilize spatially patterned nanofibrillar scaffolds and endothelial interactions for engineering spatially patterned skeletal muscle to treat muscle injury or to enhance vascular regeneration to ischemic limb tissue. Towards developing a more physiologically relevant endothelial ECM milieu, Dr. Huang will describe the generation of combinatorial ECM microarrays and reveal the role of specific combinatorial ECMs in modulating endothelial cell survival and angiogenic function in ischemia-mimetic environments. Together, these examples illustrate the importance of the ECM microenvironment for vascular regeneration.